Uses and Dosing
Cannabidiol has a wide range of functions in the human body. People are using CBD oil and CBD products for things from inflammation to anxiety, depression, and more. Please note that the FDA has not evaluated these statements and has only approved CBD (the pharmaceutical version) for the use in two types of pediatric seizure disorders.
On the internet you will find claims by many that CBD can help:
- Multiple Sclerosis
-mad cow disease
-irritable bowel syndrome (IBS)
-and much more.
This list is not all-inclusive but it gives you an of idea of the number of illnesses individuals are attempting to treat with CBD oil.
First, a little information about the absorption and bioavailability of CBD. CBD is a resin that is extracted from the plant as an oil. Oil and water do not mix, as we were all taught in grade school. This makes absorption from the digestive tract variable. It has been estimated that the amount of CBD taken by mouth that is makes it to our blood stream is around 6% due to the variable absorption and then first pass metabolism by the liver. Sublingual CBD or sprays and lozenges have poor bioavailability as well, with numbers reported at 10-20%. Some product state that they are water soluble and give numbers ranging from 75-90% absorptions. While the theories behind their suggestions are sound, there is currently not evidence to support such claims.
The half life of CBD is 14-17 hours, suggesting that the best dosing would be twice daily. Being highly lipophilic (meaning it likes to attach to fat), it rapidly distributes to organs that are high in fat or simply adipose tissue (fat tissue). Because it is lipophilic, it is possible that it can accumulate in individuals with higher fat content. Also due to its lipophilic nature, consuming it with a high-fat content meal can increase its absorption four to five times.
Some websites have listed ‘Mayo Clinic recommendations’ for dosing. We have had no reply from the sites who have shared them, and Mayo Clinic has informed us that they have never given such recommendations.
Because of the above, and the variability of each CBD product, and the countless variables such as weight, diet, metabolism, genetics, environment, and more, there is no standard dosing that can be recommended across the board. What we do recommend is starting low. There is generally a standard recommended dosage for each individual CBD product. We recommend starting much lower than that. For instance, if the CBD oil comes with a dropper and the recommended dose for that brand is a dropper full, we would recommend starting with 1-2 drops twice a day, and increasing every 5-7 days until you find the ‘sweet spot’ and see the results you are looking for. Some may need much less than others. Also note, that lower dose can be ‘activating’ which means they may act as a stimulant for some people. This is great if you are looking for energy, but perhaps not so great if you are looking for sleep.
The most reported side effects of CBD are sleepiness, decreased appetite, and diarrhea, which generally occur at higher dose, but could happen at any dose. CBD has not been shown to cause tolerance. It has actually been shown to increase receptor activity and some reports show that after a few months, you may need less CBD to get your desired results.