Agonist: substance with the capability to bind to a receptor and activate it.
Allosteric modulator: Ligand which binds to a receptor at a site distinct from the endogenous agonist and can enhance or inhibit its action.
Antagonist: substance with capability to bind a receptor and interfere with or block the action of the receptor.
Anandamide (N-arachidonoylethanolamide or AEA): A fatty acid neurotransmitter made from arachidonic acid. An endocannabinoid that has anti-inflammatory properties.
2-Arachidonoylglycerol (2-AG): Endocannabinoid AGONIST for CB-1 and CB-2 which is PRO-inflammatory.
Cannabinoid: Collective term for substances from the resin of the hemp plant
Cytochrome P450 system: is a hemeprotein that plays a key role in the metabolism of drugs and other xenobiotics
Dabbing: Inhaling the vapors of a concentrated extract of typically marijuana.
Endocannabinoids: Lipid molecules made by our body similar to substance found in the Cannabis plant and able to bind to cannabinoid receptors
Endocannabinoid system (ECS): is a widespread neuromodulatory system that plays important roles in central nervous system (CNS) development, synaptic plasticity, and the response to endogenous and environmental insults. The ECS is comprised of cannabinoid receptors, endogenous cannabinoids (endocannabinoids), and the enzymes responsible for the synthesis and degradation of the endocannabinoids.
Entourage effect: The premise that CBD is more effective with it is combined with other cannabinoids. Working together, a synergy is created that boosts the healing properties of CBD. Promoted as the reason to use full spectrum CBD.
Flavonoids: Found in plants, fruits, dark chocolate, teas. Felt to have anti-inflammatory and other beneficial properties (No FDA evidence, however).
G-protein coupled receptors: As their name implies, GPCRs interact with G proteins in the plasma membrane. When an external signaling molecule binds to a GPCR, it causes a conformational change in the GPCR. G proteins are specialized proteins with the ability to bind the nucleotides guanosine triphosphate (GTP) and guanosine diphosphate (GDP).
Hemp: Plant used to make cords and rope, construction material, paper, textiles, as well as for its edible seeds, milk, and oil. It has less than 0.3% THC by dry weight.
Homeostasis: the tendency toward a relatively stable equilibrium between interdependent elements, especially as maintained by physiological processes.
Ligand: Molecule that binds to a receptor
Palmitoylethanolamid (PEA). A Cannabinoid
Parasympathetic nervous system: one of two main divisions of the autonomic nervous system. Sometimes called the rest and digest system, the parasympathetic system conserves energy as it slows the heart rate, increases intestinal and gland activity, and relaxes sphincter muscles in the gastrointestinal tract.
Partial agonist: drugs that bind to and activate a given receptor, but have only partial efficacy at the receptor relative to a full agonist
Phytocannabinoids: Cannabinoids origination from the Cannabis plant. This term does not differentiate between CBD and THC. There are more than 100 phytocannabinoids in the Cannabis plant.
Pleiotropic: having multiple effects
Psychoactive: affecting the mind
Sympathetic nervous system; one of two main divisions of the autonomic nervous system. Its primary process is to stimulate the body's fight-flight-or-freeze response.
Terpenes: Resin from plant, responsible for taste and smell of cannabis.
Terpenophenolic: compounds that are part terpenes, part natural phenols, which means that CBD is soluble in both oil and alcohol.